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Joined 3 years ago
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Cake day: June 4th, 2023

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  • I’ve done a bit of work on this front a few years ago. We had a number of simulators that can tell you the likelihood that something binds to a specific protein, and you’re basically just searching through all possible compounds to find things that bind to a target while minimizing their interactions with other proteins that would be known to cause problems in the human body. When we find promising candidates, we send them off to a lab to synthesize and test in vitro.

    This kind of search problem isn’t exactly easy to automate mainly because naive solutions are very expensive. It’s never been a problem of outputting nonsense. The automations use the same evaluation metrics as human researchers.






  • There are many things here in Canada that suck. Is it better or worse than that of other countries? Should we try to copy what someone else is doing or come up with a different solution altogether? The way to figure that out is to critically evaluate what’s going on elsewhere, and that comes with engaging in discussions with others on those topics, which can come in the form of criticisms. We may also want to convince others that the state of things in those countries are bad and we should not try to model them, and that also often comes in the form of criticism for that foreign country.