There are so many Wine Front ends so many guides
- play on linux (https://www.playonlinux.com/)
- wine tricks (https://github.com/Winetricks/winetricks)
- winecharm (https://github.com/fastrizwaan/WineCharm)
- wineZGUI (https://github.com/fastrizwaan/WineZGUI)
- bottles (https://usebottles.com/)
- qt gui for wine (https://web.archive.org/web/http://q4wine.brezblock.org.ua/)
Games
- lutris (https://lutris.net/)
- protontricks (https://github.com/Matoking/protontricks)
- protonplus (https://protonplus.vysp3r.com/)
- portporton (https://linux-gaming.ru/)
What is your end goal? There are a lot of different ways to install Wine for different purposes.
If it’s just to run a arbitrary binary, I use Heroic and add it as a non-Epic/Amazon game. Different Wine/Proton versions can be downloaded in the settings.
You can also add them to Steam as non-steam game and enable compatibility mode in the settings.
^^ Heroic worked really well for me as well. I used it to get Affinity working. (Apart from using it for Epic Games and GOG ofc.)